Monday 16 June 2014

Drug solid solutions – a method for tuning phase transformations

Drug solid solutions – a method for tuning phase transformations
Amit Delori, Pauline Maclure, Rajni M. Bhardwaj, Andrea Johnston, Alastair J. Florence, Oliver B. Sutcliffe and Iain D. H. Oswald
CrystEngComm, 2014, 16, 5827 DOI:10.1039/C4CE00211C
 
 This paper describes a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.
 
 
 read at
 
 
 http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00211C?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-26&utm_source=toc-alert#!divAbstract

Drug solid solutions – a method for tuning phase transformations

*Corresponding authors
aStrathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, Glasgow, UK G4 0RE
E-mail: iain.oswald@strath.ac.uk;
Fax: +44 (0)141 552 2562 ;
Tel: +44 (0)141 548 2157
bSchool of Science and the Environment, Manchester Metropolitan University, Chester Street, Manchester, UK M1 5GD
E-mail: o.sutcliffe@mmu.ac.uk;
Fax: +44 (0)161 2476840 ;
Tel: +44 (0)161 2471531
CrystEngComm, 2014,16, 5827-5831

DOI: 10.1039/C4CE00211C

No comments:

Post a Comment