Medicinal Chemistry International: Drug solid solutions – a method for tuning phase transformations

Monday, 16 June 2014

Drug solid solutions – a method for tuning phase transformations

Amit Delori, Pauline Maclure, Rajni M. Bhardwaj, Andrea Johnston, Alastair J. Florence, Oliver B. Sutcliffe and Iain D. H. Oswald

CrystEngComm, 2014, 16, 5827 DOI:10.1039/C4CE00211C

This paper describes a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

read at

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00211C?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-26&utm_source=toc-alert#!divAbstract

Drug solid solutions – a method for tuning phase transformations

Amit Delori,^a Pauline Maclure,^a Rajni M. Bhardwaj,^a Andrea Johnston,^a Alastair J. Florence,^a Oliver B. Sutcliffe^b and Iain D. H. Oswald*^a

*Corresponding authors

^aStrathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, 161 Cathedral Street, Glasgow, UK G4 0RE
E-mail: iain.oswald@strath.ac.uk;
Fax: +44 (0)141 552 2562 ;
Tel: +44 (0)141 548 2157

^bSchool of Science and the Environment, Manchester Metropolitan University, Chester Street, Manchester, UK M1 5GD
E-mail: o.sutcliffe@mmu.ac.uk;
Fax: +44 (0)161 2476840 ;
Tel: +44 (0)161 2471531

CrystEngComm, 2014,16, 5827-5831

DOI: 10.1039/C4CE00211C