Maraviroc Formula: C29H41F2N5O
Maraviroc is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the CCR5 receptor, which is found on the surface of certain human cells. The chemokine receptor CCR5 is an essential co-receptor for most HIV strains and necessary for the entry process of the virus into the host cell. The drug binds to CCR5, thereby blocking the HIV protein gp120 from associating with the receptor. HIV is then unable to enter humanmacrophages and T-cells. Because HIV can also use other coreceptors, such as CXCR4, an HIV tropism test such as a trofile assay must be performed to determine if the drug will be effective.
Development and approval
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- Krauskopf, Lewis (August 6, 2007). “Pfizer wins U.S. approval for new HIV drug”. Reuters. Retrieved 2007-08-06.
- Reuters, Europe gives final approval to Pfizer HIV drug
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- ”Maraviroc reduces viral load in naive patients at 48 weeks”. AIDS Patient Care and STDs 21 (9): 703–4. September 2007. PMID 17941136.
- BBC News story: Drug ‘stops HIV’s entry to cells’
- Maraviroc data at aidsmap
- Maraviroc early access program
- New HIV Drug Recommended for Approval
- maraviroc at the US National Library of Medicine Medical Subject Headings (MeSH)